Felippe Clemente De Souza was born in Bombay, but his parents were from Siolim, Bardez, Goa. He studied medicine at the Grant College in Bombay and attained his degree in 1864. He was soon selected for a posting at the Rustamjee Jamsetgee Jegeebhoy hospital in Daman. After Serving in Daman, Felippe Clemente De Souza returned to Bombay and had a successful practice in Mahim, Bombay.