Fr Domingos da Silva S.J. was incharge at the Holy Spirit Church Margao from 1569 till 1576. During his tenure the other Priests based at Holy Spirit Church, Margao were Fr Pero Collaco, Bro Pero Collaco, Bro Pedro Affonso and Bro Domingos Freyre who all later worked at the church of St Michael Orlim.
The other priests who worked in the church also included, Fr Baltazar Gago, Fr gaspar d’ Ozouro, Bro Pero Diniz, Bro Yuliao Viera, Bro Antonio Rebello, Fr Diogo Silva SJ,
The Priests who worked in Salcete but based in Margao are Fr Antonio Da Costa, Fr Antonio Prestinos, Fr Manoel Pereira, Fr Joseph Victoria, Fr Antonio Da Costa, Bro Pero Afonso, Bro Jeronimo Rebello, Fr Francisco Anriques, Bro Miguel Rodrigues, Bro Andre de Lavesolo.
Since Margao was the College for the Priests, the following were also based in Margao, Antonio Costa, Joao Lopes, Gasper Coelho, Antonio Diniz, Ferdinando Nunes, Pedro Afonso, Juliao Viera, Estevao Ribeiro, Pedro Cruz, Antonio Rebello.